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Collaboration & partnerships

Collaboration & partnerships

Collaboration and partnerships

Rasmus Just

Rasmus Just

Head of Global Business Development

Morten Jarlstrup

Morten Jarlstrup

Director, Global Business Development

Loic Derrien

Loic Derrien

Director, Global Business Development

Partnering interests

At ALK, partnerships are fundamental for our continued business development. We are fueled by commitment to innovate and continuously leverage the collective strengths of our partners to be able to deliver cutting edge treatment solutions to people living with allergy. Collaboration is key to our success, and we actively seek partners who share our commitment for developing advanced treatments.

By partnering with ALK, you will gain access to our extensive R&D and immunology expertise, as well as our proven track record of global clinical development and commercialisation. We are currently seeking innovative preclinical or clinical stage assets in allergic or inflammatory diseases, with a strong scientific rationale and an established IP position.

Who to contact

Name: Rasmus Just

Title: Head of Global Business Development

Contact details: RJUDK@alk.net

Last updated: 15.11.2024

Real-world evidence

Healthcare professionals

Real-world evidence

From clinical to real-world evidence

Allergy immunotherapy (AIT) has evolved significantly over the last decade, triggered by the need for more evidence-based medicine. ALK has worked with the allergy community to develop the fields' most robust clinical trial programme, enrolling over 25,000 patients, enabling prescribing decisions to move from experience-based to evidence-based. But ideal-world evidence alone can only tell you so much.​

That is where our programme Real-world Evidence in Allergy (REWEAL) comes in, demonstrating how AIT works in the real world.

Why was REWEAL initiated?

REWEAL – best of both worlds

Comprising patient data from independent sources across multiple countries, REWEAL brings physicians best-in-class real-world evidence. It reveals the benefits of AIT for people with allergy – from improvements in quality of life and reduced drug burden to disease modification and other long-term outcomes.

Our goal is to help inform the right treatment decision by providing the best in both clinical and real-world evidence.​

REWEAL – Real patients. Real questions. Answered

Have you ever

wondered if clinical

study outcomes of AIT 

are generalisable to 

the real world?

Time to REACT in AIT

With the REACT-study we aim to complement existing evidence from randomised controlled trials and address some key unanswered questions within AIT with real-world evidence. The study assesses the long-term effectiveness of AIT on both allergic rhinitis and asthma including more than 92,000 patients for up to nine years.

REACT study design
The REACT study, a retrospective cohort study
Subgroup analyses of the REACT study
Last updated: 17.12.2024

Our data

Healthcare professionals

Our data

From clinical trials to real-world evidence

We focus on expanding the access for healthcare professionals and people living with allergies to evidence-based allergy immunotherapy as well as strengthening the evidence around burden of disease, disease modification, and new indications. Here you can explore more about our commitment to safety and efficacy of our treatment solutions for allergic disease, our key sublingual immunotherapy (SLIT) clinical trials and real-world evidence as well as sharing of our clinical data.

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Clinical trials

Our clinical trials commit to investigating the safety and efficacy of specific treatment of allergy and prevention of disease in a controlled setting. Learn more about our co-operations, areas of particular interest, and completed key SLIT randomised controlled trials.

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Real-world evidence

In our real-world studies, we evaluate the safety and effectiveness of specific treatment of people living with allergy in an uncontrolled setting – the real world, where environmental, behavioural, and other every-day life factors are included. Real-world evidence is therefore increasingly used in healthcare decision making.

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Clinical data sharing

In the spirit of transparency, and in compliance with industry guidelines, we share details of our clinical trials to help health care professionals and scientists improving the understanding of allergic disease and potential treatment options.

Last updated: 11.12.2024

Clinical trials

Healthcare professionals

Clinical trials

Commitment to safety and efficacy

ALK has a commitment to invest in studying the safety and efficacy of its products. Our R&D department designs and manages our clinical trials in co-operation with university hospitals and allergy specialists. The clinical trials focus on the specific treatment and prevention of allergic disease. For our sublingual immunotherapy (SLIT)-tablets, a global development programme is conducted in collaboration with several partners.

When investigating allergy treatments and indications, we are particularly interested in whether patients’ symptoms and need for symptom-relieving medication have decreased, whether their quality of life has improved, if progression of the disease has slowed down or reversed as well as the overall cost-effectiveness versus existing products.

Our key SLIT-tablet randomised controlled trials

Our SLIT-tablets build on the legacy of subcutaneous immunotherapy, which was discovered in the early 20th century. In 2002, our SLIT-tablet for grass allergic rhinoconjunctivitis was tested in humans for the first time.

Below we have collected our completed key SLIT-tablet randomised, double-blinded, and placebo-controlled clinical trials investigating the safety and efficacy in grass, tree, ragweed, and house dust mite (HDM) allergic rhinoconjunctivitis, respectively. In addition, two of our completed key HDM SLIT-tablet trials investigated the safety and efficacy in allergic asthma.


Grass SLIT-tablet


Tree SLIT-tablet


Ragweed SLIT-tablet


HDM SLIT-tablet


Grass SLIT-tablet

GT-08

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Long-term (five seasons)

Region: Europe

Age group: Adults

No. of participants: 634

ClinicalTrials: NCT00227279

EudraCT: 2004-000083-27

GT-12

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: Germany

Age group: Children and adolescents

No. of participants: 253

ClinicalTrials: NCT00408616

EudraCT: 2006-003415-46

P05238

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: North America

Age group: Adults

No. of participants: 439

ClinicalTrials: NCT00562159

P05239

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: North America

Age group: Children and adolescents

No. of participants: 345

ClinicalTrials: NCT00550550

P08067

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: North America

Age group: Children, adolescents, and adults

No. of participants: 1,501

ClinicalTrials: NCT01385371

GT-21/GAP

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Long-term (five seasons)

Region: Europe

Age group: Children and adolescents

No. of participants: 812

ClinicalTrials: NCT01061203

EudraCT: 2009-011235-12


Tree SLIT-tablet

TT-03

Disease area: Allergic rhinoconjunctivitis

Phase: II

Follow-up: 24 weeks

Region: Environmental exposure chamber (Europe)

Age group: Adults

No. of participants: 219

ClinicalTrials: NCT02481856

TT-04

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: Europe

Age group: Adolescents and adults

No. of participants: 634

EudraCT: 2015-004821-15

TT-06/TreeTop

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: Canada and Europe

Age group: Children and adolescents

No. of participants: 952

ClinicalTrials: NCT04878354

EudraCT: 2020-004372-17


Ragweed SLIT-tablet

P05233

Disease area: Allergic rhinoconjunctivitis

Phase: II/III

Follow-up: One year

Region: North America

Age group: Adults

No. of participants: 565

ClinicalTrials: NCT00783198

P05234

Disease area: Allergic rhinoconjunctivitis

Phase: II/III

Follow-up: One year

Region: North America and Europe

Age group: Adults

No. of participants: 784

ClinicalTrials: NCT00770315

EudraCT: 2008-003864-20

P008

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: Single-season

Region: North America and Europe

Age group: Children and adolescents

No. of participants: 1,025

ClinicalTrials: NCT02478398

EudraCT: 2014-004341-27


HDM SLIT-tablet

MT-02

Disease area: Allergic rhinoconjunctivitis and allergic asthma

Phase: II/III

Follow-up: One year

Region: Europe

Age group: Adolescents and adults

No. of participants: 604

ClinicalTrials: NCT00389363

EudraCT: 2006-001795-20

MT-04/MITRA

Disease area: Allergic asthma

Phase: III

Follow-up: Up to 78 weeks

Region: Europe

Age group: Adults

No. of participants: 834

ClinicalTrials: NCT01433523

EudraCT: 2010-018621-19

MT-06/MERIT

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: One year

Region: Europe

Age group: Adults

No. of participants: 992

ClinicalTrials: NCT01454544

EudraCT: 2011-002277-38

P003

Disease area: Allergic rhinoconjunctivitis

Phase: II

Follow-up: Up to 76 weeks

Region: Environmental exposure chamber (Europe)

Age group: Adults

No. of participants: 124

ClinicalTrials: NCT01644617

EudraCT: 2012-001855-38

TO-203-3-2

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: One year

Region: Japan

Age group: Adolescents and adults

No. of participants: 946

JapicCTI: 121848 (ENG)

P001

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: One year

Region: North America

Age group: Adolescents and adults

No. of participants: 1,482

ClinicalTrials: NCT01700192

MT-12/MATIC

Disease area: Allergic rhinoconjunctivitis

Phase: III

Follow-up: One year

Region: North America and Europe

Age group: Children

No. of participants: 1,460

ClinicalTrials: NCT04145219

EudraCT: 2019-000560-22

Compliance with guidelines

In compliance with industry guidelines, more information about all our clinical trials can be found via the freely public registries ClinicalTrials.gov and EudraCT as well as on the page Clinical data sharing.

Last updated: 19.03.2025

Science and technology

Science and technology

We are committed to providing innovative solutions to people with allergy using cutting-edge science

ALK has a long track record in breakthrough discoveries in allergy research. Working closely with physicians and academia including universities and research institutions has been a natural ingredient of our 100-year journey as a company. This has resulted in advancements in diagnostic solutions and continuous improvements in the safety and effectiveness of AIT vaccines and of allergy diagnosis and management globally.

New technologies

We are constantly exploring new emergent technologies evaluating their potential relevance for providing improved solutions for people with allergy.

One such example is applying allergen extracts daily under the tongue formulated in fast dissolving tablets. This approach was pioneered by ALK scientists and is now offered to millions of people with allergy at a global scale covering a broad range of major allergies.

Biomarkers and drug discovery

Through decades of clinical research and development we have generated new knowledge and insights from a comprehensive biobank of samples from people with allergy and people undergoing treatment with allergy immunotherapy.

We are committed to advancing the understanding of the allergic disease. This covers mechanistic research aimed at identifying potential biological pathways that may be targeted for therapeutic effect and biomarkers potentially optimising use of existing and future treatments.

Success through collaborations

We have always believed in the importance of open innovation and partnership models to advance innovation in allergy research. Excellence in science is one of our core ambitions and, we believe, required to improve the understanding of the allergic disease aiming at advancing patient care.

Working with academic partners, we have for decades been on the forefront of research within cellular and molecular pathways of the allergic inflammation, most recently exemplified by the discovery of the IgE memory B cell.

ALK and McMaster researchers discover new cell that remembers allergies | ALK.

Last updated: 01.11.2024

Digital innovation

Digital innovation

Delivering data-driven insights to improve the life of people with allergy

Artificial Intelligence (AI) holds the potential to support us in unfolding the complex nature of allergic disease to both help potential development of novel treatments and to empower people living with allergy. Our focus is on using AI technology to assist in clarifying diagnosis and shortening the path to develop innovative treatment solutions.

Understanding allergic disease

As a leader in allergy research with data from more than 20 clinical trials and +25 years of lab work, we aim to use data science and AI to lead us towards delivering continued scientific and medical breakthroughs.

One such recent breakthrough is our discovery of the cellular basis of allergic memory paving the way for an improved understanding of allergic disease.

ALK and McMaster researchers discover new cell that remembers allergies | ALK

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Data-driven drug discovery

We are implementing cutting edge data platforms and new tools to enhance our drug discovery pipeline and transform how we:

  • Identify novel targets
  • Optimise lead candidates
  • Assess immunogenicity
Real-world impact

We are using AI and machine-learning algorithms that may improve the daily lives of people with allergy and serve to understand the global trends in allergy and allergy related diseases. 

Through mobile apps and wearable devices, we are exploring new ways of measuring allergic burden with the aim to improve quality of life for the individual patient and assist in guiding them towards optimal treatment.

Last updated: 05.11.2024

Clinical data sharing

Sharing our clinical trials data

In the spirit of transparency, and in compliance with industry guidelines, ALK shares details of its clinical trials.

As a responsible, ethical, research-driven pharmaceutical company, we support the sharing of clinical trial information to help doctors and scientists further their understanding of allergic disease and potential treatment options.

At the same time, and in accordance with industry guidelines, we are also committed to safeguarding the privacy of patients, the integrity of regulatory authorities, and the intellectual property of trial sponsors.

A range of ALK policies and documents outline our approach to sharing clinical trials data and how to request access.

ALK's policy for data sharing can be downloaded here

In accordance with EFPIA’s and PhRMA´s “Principles for Responsible Clinical Trial Data Sharing” guidelines, ALK is committed to responsible sharing of clinical trial data in a manner that safeguards the privacy of patients, respects the integrity of national regulatory systems, and protects the intellectual property of the sponsor.

How to apply

To apply for access to clinical trial data, please complete and submit the research proposal form including CVs and a statistical analysis plan to ClinicalTrials@alk.net.

After successful submission, you will receive a confirmation of receipt and an estimated timeline for handling of your application.

Please note that if you are granted access to data, you will need to sign the data sharing agreement.

If funding and/or approvals are required to perform the research e.g. approvals from ethics committees, it is the responsibility of the applicant to secure this.

Review of application

Access to data may be provided following review of the application by a scientific review board including independent academic scientists and healthcare professionals.

The review process and role of the independent scientific review board is described in the scientific review board charter. Review criteria include general assessment, the patient’s perspective, a scientific perspective and a methodology assessment.

If access to data is granted, you will be given an estimated timeline for data sharing. An independent third party will analyse the data according to the statistical analysis plan and forward the results directly to you.

Applicants must publish the results as stated in the submitted publication plan.

Synopses

House dust mite SLIT-tablet

House dust mite SLIT-tablet

Grass SLIT-tablet

Grass SLIT-tablet

Tree SLIT-tablet

Ragweed SLIT-tablet

Ragweed SLIT-tablet

Tree SLIT-tablet

Other products

Other products

Last updated: 11.12.2024

Our Science

Our science

With 100+ years of experience in pioneering allergy treatment, nobody knows allergy like us.

At the core of ALK, innovation thrives. We have spent the past 100+ years pioneering within the field of allergy with the continued purpose of helping more people living with allergy.

Our deep understanding of the underlying biology and how allergy works has given us the foundation to develop a range of allergy immunotherapy treatments and management options, forming the core of our current product range. We remain committed to advancing science and are dedicated to innovate and expand our Research & Development (R&D) pipeline, continuously providing novel concepts within allergy research and treatment.

Our scientific focus is centered around respiratory allergy, food allergy, anaphylaxis and adjacent diseases areas.

Are you a young scientist making significant contributions within the field of allergy research? Apply for the prestigious Henning Løwenstein Research Award 2025 now! Deadline is 15 August 2025.

Our scientific focus areas

Our scientific focus is to advance science and identify biological pathways to lead discovery and development of innovative medicines within allergy and adjacent therapy areas. We are implementing cutting-edge technologies and new data platforms to accelerate our drug discovery pipeline and transform how we work across R&D. Our mission is to improve the lives of people living with allergy.


Respiratory allergy 


Food allergy


Anaphylaxis


Adjacent therapy areas 

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Respiratory allergy

Over 500 million people globally live with allergic rhinitis (AR), and despite symptom-relieving treatment, many live with an uncontrolled disease.

Early intervention is key to addressing the progression of allergic diseases, including the atopic march.

At ALK, we remain committed to advancing science in respiratory allergy. We will continue to strengthen our leadership in allergy immunotherapy and have a strong focus on disease modification and prevention of allergic co-morbidities.

Our translational research seeks to uncover methods for preventing allergic asthma as well as to assess how environmental elements including viruses and genetic variables may impact the progression of asthma and the effectiveness and tolerability of treatment options.

Our pipeline

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Food allergy

Food allergy is a potentially life-threatening disease with increasing prevalence in many regions. Currently affecting an estimated 4% of all children worldwide.

For people living with this disease, exposure to certain foods can lead to anaphylaxis, a potentially life-threatening condition that requires immediate medical attention. Peanut allergy is one of the food allergies leading to the highest rates of anaphylaxis.

ALK is building a presence in peanut allergy, and we are determined to advancing the science to help people with food allergies.

Drawing on a century of expertise in allergy medicine, we are dedicated to developing innovative treatments for food allergy through immunology research. Our research aims to explore innovative therapies that may modify the course of food allergies and improve patient outcomes.

Our pipeline

Image description
Anaphylaxis

Anaphylaxis is a severe and acute allergic reaction that occurs when the immune system overreacts to a certain allergen. The health burden imposed by the risk of anaphylaxis can have a considerable impact on the quality of life for both patients and their relatives.

We aim to leverage our scientific legacy in severe allergies and remain dedicated to improving the lives of people at risk of anaphylaxis.

We strive to deliver new patient-friendly adrenaline administration solutions, designed for ease of use.

Our pipeline

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New adjacent areas

We are founded in allergology and immunology and are leveraging our deep knowledge in ”Type 2” immune mechanisms and dysregulation with the ambition to discover new targets and develop improved solutions for people living with these complex allergic disorders.

Our team of scientists is committed to uncover new pathways and advance science within mast cells and IgE memory B-cells, both of which play pivotal roles in the allergic response.

Our goal is to explore treatments that aim to rebalance the immune system and improve patient outcomes.

Our pipeline

Development pipeline

Our commitment to helping people and families living with the burden of allergy drives our discovery and development of innovative medicines addressing the unmet needs within allergy. With a strong foundation built on science and biology understanding, we are continuously advancing our pipeline to deliver novel solutions.

Explore our development pipeline

For more information, please refer to our company announcements. For healthcare professionals, more information can be found here.

Read more about our scientific focus areas.

Clinical trials

Information about our clinical trials can be found via the freely public registries clinicaltrialregister.eu, clinicaltrials.gov or on this page Clinical trials synopses.

Last updated: 05.05.2025

Healthcare Professionals (EDITED VERSION)

Healthcare professionals

The digital allergy portal

With 100 years of experience, nobody knows allergy like us.

The allergy digital portal provides healthcare professionals with access to the latest information, medical education resources and personalised services on allergy immunotherapy, including easy access to product information, scientific literature and presentations, clinical data and much more.

Providing information in the field of specific allergy

Henning Løwenstein Research Award
The Henning Løwenstein Research Award was established and dedicated to researcher Henning Løwenstein by ALK on his 25th anniversary of working at the company. This is a biennial award given to a young scientist who has shown excellence within the field of allergy research.
Real World Evidence
Learn more about real world evidence (RWE), about patients treated with AIT, and the potential challenges of generating evidence from the real world. Additionally, you will find experts' perspectives on the relevance of RWE and how such AIT studies can offer the best of both worlds, by providing best in class Randomized Clinical Trial (RCT) data, as well as best in class RWE.
Webinars
ALK presents interactive discussions on co-administration of SLIT-tablets and how the COVID-19 pandemic has changed, and will further change the face of healthcare, with insights from global allergy experts. The webinars consist of clinicians’ perspectives and panel discussions.
Last updated: 03.09.2024

Henning Løwenstein Research Award 2021 (EDITED VERSION)

The Henning Løwenstein Research Award

Award to an excellent young scientist within the field of allergy

Watch previous award ceremonies

2024 Henning Løwenstein award - won by Kelly Bruton

The Henning Løwenstein Research Award is a biennial award given to a young scientist who has shown excellence within the field of allergy.

Over the last few decades allergy has increased in prevalence to become the most common chronic disease in modern societies. The causes for this sudden change are not entirely clear, although they seem to be linked to ‘modern lifestyle’.

It appears that allergy immunotherapy is the only treatment to treat the cause, induce immunological tolerance and to prompt disease modification. Disease modification implies long term effect, prevention of asthma in children with allergic rhinitis and prevention of new allergies.

In ALK we believe that reinforced efforts in research on the characteristics and treatment of respiratory allergic disease will lead the way for future achievements to the benefit of people with allergies all over the world.

2021 Henning Løwenstein Research Award - won by Julia Esser-von Bieren

Previous award ceremonies and winners

The Henning Løwenstein Research Award

2024: Kelly Bruton, Stanford University, United States of America 

2021: Julia Esser-von Bieren, Technical University, Munich, Germany

The ARIA-EUFOREA Henning Løwenstein Research Award

2019: Kornel Golebski, University of Amsterdam, the Netherlands

The WAO Henning Løwenstein Research Award

2015: Stefanie Eyerich, Technical University and Helmholtz Center, Munich, Germany 

2013: Bianca Schaub, Ludwig-Maximilian-University, Munich, Germany 

2011: Zoulfia Allakhverdi, University of Montreal, Canada, and Natalija Novak, University of Bonn, Germany 

2009: Stephen J Till, Imperial College, London, United Kingdom 

2007: Barbara Bohle, Medical University of Vienna, Austria

The Henning Løwenstein Research Award

2005: Omid Akbari, Harvard University, United States of America 

2004: Christopher Lynn Kepley, Commonwealth University of Virginia, United States of America 

2003: Erika Ganglberger, University of Vienna, Austria 

2002: Miriam Fleur Moffatt, University of Oxford, United Kingdom 

2001: Eckard Hamelmann, Humboldt-University of Berlin, Germany 

2000: Mark Larché, Imperial College, London, United Kingdom

Last updated: 04.09.2024